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Seth W. Donahue

Ph.D.
Associate Professor

Email: swdonahu@mtu.edu

Office: 309 M&M Building

Telephone: 906-487-1729
Fax: 906-487-1717

Michigan Technological University
Department of Biomedical Engineering
309 Minerals and Materials Eng. Bldg.
1400 Townsend Drive
Houghton, MI 49931-1295

Publications on PubMed

Research Interests: The role of mechanical forces in bone adaptation, bone cell signaling, stress fractures, osteoporosis, and tissue engineering

Research Projects:

1. Bone Metabolism in Black Bears: Analysis of serum hormones and bone remodeling markers in hibernating bears

Hibernating bears as a model for preventing disuse osteoporosis

Parathyroid hormone may maintain bone formation in hibernating black bears (Ursus americanus) to prevent disuse osteoporosis

Article in the NewScientist
Article on ScienCentral

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2. Bone Cell Mechanotransduction: Mechanically induced bone cell signaling and gene expression

Osteoblastic cells have refractory periods for fluid-flow-induced intracellular calcium oscillations for short bouts of flow and display multiple low-magnitude oscillations during long-term flow		 1
3. Bone Tissue Engineering: Mechanical stimulation in 3-dimensional bone cell cultures

Mechanical stimulation of MC3T3 osteoblastic cells in a bone tissue-engineering bioreactor enhances prostaglandin E2 release

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4. Bone Mechanics: Bone material properties and modeling of fluid flow in bone

A fatigue microcrack alters fluid velocities in a computational model of interstitial fluid flow in cortical bone

The tensile strength of black bear (Ursus americanus) cortical bone is not compromised with aging despite annual periods of hibernation

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View Movie of breaking bear bones 2 Mb WMV
5. Quantitative Histomorphometry of Bone: Bone remodeling and fatigue microcrodamage

Bone strain and microcracks at stress fracture sites in human metatarsals

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Boneheads Softball team

Courses:

BE 3750: Human Biomechanics—Fall

BE 4100/5100: Cell and Tissue Mechanics— Spring

The other Dr. Donahue