Anisotropic Micro-fibrous Scaffolds for Nerve Regeneration Applications
Spinal Cord Regeneration and Regeneration within the Peripheral Nervous System

Student Researcher: Jared Cregg and Sarah McIntyre – Undergraduate Students, Biomedical Engineering

Neurons use gradients of extracellular matrix molecules to direct axonal outgrowth. We have shown previously that aligned micro-fibrous scaffolds direct axonal extension. We are using novel techniques to create a laminin-1 gradient onto the surface of our aligned fibrous scaffolds. We believe that the addition of a gradient will increase the rate of axonal outgrowth creating an environment which may facilitate faster neuronal regeneration within the spinal cord or peripheral nervous system.